Tocotrienol Rich Fraction Modulates the Expression of Synaptogenic RNAs in Neurons of Caenorhabditis Elegans

Background: One of the main concerns of getting older is the experience of impairments in memory function. Synapses play an important role in learning and memory during aging and their deterioration is associated with reactive oxygen species. Among the many vitamin E analogues, tocotrienols are known to have neuroprotective effect as well as remarkable antioxidant activities. Recent in vitro studies have successfully extracted embryos from C. elegans to develop neurons, muscles and epithelial cells.

Effects of Vitamin E on Bone Oxidative Parameters during Fracture Healing of Postmenopausal Osteoporosis Rat Model

Osteoporosis increases the risk of bone fracture and may interfere fracture healing. Studies have proven that vitamin E promoted fracture healing of osteoporotic bone. The objective of this study is to determine whether the antioxidative actions of tocopherol and tocotrienol promotes the late-phase fracture healing of ovariectomised rats. Thirty-two female Sprague-Dawley (200g - 250g) rats were divided among four groups: Sham (SO), Ovariectomised-control (OVXC), Ovariectomised + 60mg/kg alpha-tocopherol (ATF), and ovariectomised + 60mg/kg tocotrienol enrich fraction (TEF).

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