Tocotrienol Rich Fraction Modulates the Expression of Synaptogenic RNAs in Neurons of Caenorhabditis Elegans

Background: One of the main concerns of getting older is the experience of impairments in memory function. Synapses play an important role in learning and memory during aging and their deterioration is associated with reactive oxygen species. Among the many vitamin E analogues, tocotrienols are known to have neuroprotective effect as well as remarkable antioxidant activities. Recent in vitro studies have successfully extracted embryos from C. elegans to develop neurons, muscles and epithelial cells.

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