Effects of Prolonged Intravenous Phosphate Administration On Rabbit’s Serum Calcium

Phosphate administration mediates the genesis of the parathyroid gland hyperplasia thus modulating the parathyroid hormone synthesis. Phosphate retention will consequently lead to hyperparathyroidism which can be detected by markedly high serum calcium levels. The objective of this study is to evaluate the effects of prolonged intravenous phosphate administration on serum calcium and to establish the hyperparathyroidism animal model of rabbits. Ten healthy New Zealand White does (female rabbits) aged 4 months with body mass between 2.0 to 2.5 kg were used.

Bone Analysis of Young Adult Rabbit Femur via Micro-Computed Tomography

Micro-computed tomography is a useful tool for bone evaluation as various parameters are readily available. It has been widely used especially in small animal imaging for preclinical investigation. The Skyscan 1176 is one of the micro-computed tomography systems available that provide high performance scanning. The purpose of this paper is to provide a reference document for basic steps utilising Skyscan 1176 for ex-vivo young adult rabbit femur and similar sample.

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