Combined effects of Eurycoma longifolia and Calcium on Bone Metabolism of Orchidectomised Male Rats

Background: Osteoporosis is characterized by low bone mass and destruction of bone microarchitecture. Androgen deficiency or hypogonadism is one of the major risk factors of osteoporosis in men. Testosterone replacement therapy (TRT) is the main treatment for hypogonadal osteoporosis but may cause side effects such as prostate cancer and cardiovascular diseases. An alternative treatment is required, with similar efficacy but minimal side effects.

The Suitable Androgen-Deficient Models for Investigation of Eurycoma Longifolia, A Pro-Androgenic Agent

There are several androgen deficiency models that can be used to study the effects of pro-androgenic agents such as Eurycoma longifolia (EL). Suitable model must be chosen so that the androgenic effects of the agents tested could be demonstrated. As an example, EL was postulated to produce androgenic effects by stimulating the testosterone release by the testes. This makes the orchidectomy rat model of androgen deficiency unsuitable because EL cannot act with the removal of both testes.

Effects of Vitamin E on Bone Oxidative Parameters during Fracture Healing of Postmenopausal Osteoporosis Rat Model

Osteoporosis increases the risk of bone fracture and may interfere fracture healing. Studies have proven that vitamin E promoted fracture healing of osteoporotic bone. The objective of this study is to determine whether the antioxidative actions of tocopherol and tocotrienol promotes the late-phase fracture healing of ovariectomised rats. Thirty-two female Sprague-Dawley (200g - 250g) rats were divided among four groups: Sham (SO), Ovariectomised-control (OVXC), Ovariectomised + 60mg/kg alpha-tocopherol (ATF), and ovariectomised + 60mg/kg tocotrienol enrich fraction (TEF).

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