Effects of Prolonged Intravenous Phosphate Administration On Rabbit’s Serum Calcium

Phosphate administration mediates the genesis of the parathyroid gland hyperplasia thus modulating the parathyroid hormone synthesis. Phosphate retention will consequently lead to hyperparathyroidism which can be detected by markedly high serum calcium levels. The objective of this study is to evaluate the effects of prolonged intravenous phosphate administration on serum calcium and to establish the hyperparathyroidism animal model of rabbits. Ten healthy New Zealand White does (female rabbits) aged 4 months with body mass between 2.0 to 2.5 kg were used.

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