Isolation of Mitochondria and Measurement of Oxygen Consumption Rate by High-resolution Respirometry in Rat Hippocampus

Background: Hippocampus plays an important role in memory and learning. Dysfunction of mitochondrial bioenergetics has been implicated in neurodegenerative disorders such Alzheimer disease. Oxygen consumption rate (OCR) is a useful indicator of mitochondrial function. Mitochondria isolated for OCR measurement need to have well intact function. This study aimed to describe the measurement of OCR by high resolution respirometry (HRR) in mitochondria isolated from rat hippocampus

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