The Suitable Androgen-Deficient Models for Investigation of Eurycoma Longifolia, A Pro-Androgenic Agent
Vol. 3 Issue 1 : 2015



There are several androgen deficiency models that can be used to study the effects of pro-androgenic agents such as Eurycoma longifolia (EL). Suitable model must be chosen so that the androgenic effects of the agents tested could be demonstrated. As an example, EL was postulated to produce androgenic effects by stimulating the testosterone release by the testes. This makes the orchidectomy rat model of androgen deficiency unsuitable because EL cannot act with the removal of both testes. This review discussed the advantages and limitations of several androgen deficiency models and attempted to recommend the best model for studies on EL.