The Effects of Vitamin E Mixture on the Bone Structure of Normal Rat Model
Vol. 1 Issue 1 : 2013


Background: Tocopherol and tocotrienol are vitamin E which were shown to protect bone against osteoporosis. Most bone studies used either alpha-tocopherol or tocotrienols but mixture of both forms of vitamin E was not adequately investigated. This study was conducted to deter-mine the effects of alpha-tocopherol and tocotrienols combination on the bone structure of normal male rats.
Methods: Sixteen male Sprague-Dawley rats were divided into NC (normal control) and Toco (Tocomin@, mixture of tocopherols and tocotrienol isomers) groups. To-comin@ was given via daily oral gavages at the dose of 60 mg/kg. Following four months of treatment, the rats were euthanized and femora dissected out for bone histomorphometry.
Results: The Toco group was found to have significantly better bone structural parameters (higher BV/TV, TbN but lower TbSp) than the NC group. In conclusion, Tocomin@ (mixture of alpha-tocopherol and tocotrienol iso-mers) supplementation was able to improve the bone structure.
Conclusion: These results warranted a clinical study to confirm the beneficial effects of vitamin E on bone health.