Effects of Vitamin E on Bone Oxidative Parameters during Fracture Healing of Postmenopausal Osteoporosis Rat Model
Vol. 2 Issue 1 : 2014


Osteoporosis increases the risk of bone fracture and may interfere fracture healing. Studies have proven that vitamin E promoted fracture healing of osteoporotic bone. The objective of this study is to determine whether the antioxidative actions of tocopherol and tocotrienol promotes the late-phase fracture healing of ovariectomised rats. Thirty-two female Sprague-Dawley (200g - 250g) rats were divided among four groups: Sham (SO), Ovariectomised-control (OVXC), Ovariectomised + 60mg/kg alpha-tocopherol (ATF), and ovariectomised + 60mg/kg tocotrienol enrich fraction (TEF). The right femora of the rats were fractured eight weeks after ovariectomy and vitamin E supplementations were given two days post-fracture, by oral gavage, six days per week, for eight weeks. The rats were euthanised and the right femora were harvested for bone oxidative status determination (TBARS, SOD, GPX, and catalase). Result from the study showed no significant changes for all oxidative parameters measured (MDA, SOD, GPX and Catalase). Supplementation of α-tocopherol and tocotrienol had no effects on the bone oxidative status during late phase fracture healing of postmenopausal osteoporosis rat model. These anti-oxidative actions of vitamin E may be important only during the early-phase of fracture healing