Article

Effects of Prolonged Intravenous Phosphate Administration On Rabbit’s Serum Calcium
Vol. 3 Issue 3 : 2015

Abstract

Phosphate administration mediates the genesis of the parathyroid gland hyperplasia thus modulating the parathyroid hormone synthesis. Phosphate retention will consequently lead to hyperparathyroidism which can be detected by markedly high serum calcium levels. The objective of this study is to evaluate the effects of prolonged intravenous phosphate administration on serum calcium and to establish the hyperparathyroidism animal model of rabbits. Ten healthy New Zealand White does (female rabbits) aged 4 months with body mass between 2.0 to 2.5 kg were used. Their bloods were withdrawn 1 week before and 5 months after the intravenous phosphate administration for serum calcium evaluation. Result from the study showed that the rabbit’s serum calcium level after 5 months of the intravenous phosphate administration has increased compared to 1 week before the administration. Prolonged intravenous phosphate administration increased the serum calcium level and can be suggested as one of the ways to establish hyperparathyroidism in the animal model.