In diabetic condition, wound healing may be impaired or delayed due to high reactive oxygen species (ROS) and low antioxidant levels.
Vitamin E is an antioxidant which exerts both systemic and topical effects. The effects of vitamin E on wound healing remains controversial.
Numerous studies have been carried out to observe the ability of vitamin E in modulating signal transduction and gene expression.
However, the detailed molecular mechanisms are not yet clear. Vitamin E may promote healing by supressing ROS generation
since vitamin E has shown inhibitory effects on activities and expression of ROS-generating enzymes. The effects of vitamin E may
depend on its concentration and the presence of oxidants/antioxidants. The objective of this article is to review the role and mechanism
of action of vitamin E in wound healing process at cellular and molecular level.