Research Articles

Tocotrineol Rich Fraction (TRF) Increases Viability of Senescent Fibroblast

The Hayflick limit is a theory that covers the definition of in vitro replicative senescence. It states that proliferating cells reach the limit of replicative potential after a series of sub-cultivations. Tocotrienol has been touted as it exhibits a higher significant radical scavenging activity as compared to α-tocopherols. In this study, we evaluated the effect of tocotrienol rich fraction (TRF) on the viability of young and senescent fibroblast and its possible modulation of oxidative stress.

Attitudes, perception and knowledge of general practitioners towards adverse drug reaction (ADR) reporting in Malaysia – A pilot study

Background: The main form of pharmacovigilance system in Malaysia is the spontaneous voluntary reporting system for adverse drug reaction (ADR) set up by the Malaysian Adverse Drug Reactions Advisory Committee (MADRAC) and is plagued by low reporting rates. This pilot study aims to determine the practice, knowledge, attitude and perception of GPs in Malaysia towards ADR reporting.

The Effects of Vitamin E Mixture on the Bone Structure of Normal Rat Model

Background: Tocopherol and tocotrienol are vitamin E which were shown to protect bone against osteoporosis. Most bone studies used either alpha-tocopherol or tocotrienols but mixture of both forms of vitamin E was not adequately investigated. This study was conducted to deter-mine the effects of alpha-tocopherol and tocotrienols combination on the bone structure of normal male rats.

Antifungal susceptibility patterns of germ tube positive versus germ

Background : Germ tube test is commonly used for presumptive identification of Candida species. This study compared the antifungal susceptibility patterns of germ tube positive with germ tube negative Candida isolates.


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