Research Articles

Determinants of Patients at Risk of Developing Obstructive Sleep Apnea in a Primary Care Clinic

Obstructive sleep apnea (OSA) is associated with multiple medical and psychosocial impacts. Current evidence on  individuals at risk of developing OSA in Malaysia particularly at primary care setting is scarce. This study aimed to determine the magnitude of  patients at risk of developing OSA attended an suburban primary care clinic and associated factors in southern Malaysia.

Xenobiotic Metabolising Enzymes (CYP1A1, CYP2E1 and NAT2) Gene Polymorphism in Malaysian Students

 Objectives
Xenobiotic metabolising enzymes (XME) which modify disease susceptibility/ outcome in certain ethnic groups, showed ethnic dependent polymorphism. The aim of this study was to determine XME gene polymorphism in Malays as a major ethnic group in Kuala Lumpur.
 
Methods
Blood or buccal swab samples were collected from 137, 14-year-old students from two schools in Wilayah Persekutuan Kuala Lumpur. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
 
Results

Ischemic cerebral infarction post-fibrinolytic therapy with tenecteplase for myocardial infarction

Modulation of Plasma Antioxidant Vitamins and Oxidative Stress Biomarkers by Tai Chi Exercise

Tai Chi is an ancient Chinese martial art practiced as a form of exercise and used as an alternative treatment for certain diseases. It is a very suitable form of exercise for the elderly as it is low impact and involves slow rhythmic movements.

Impact on Knowledge in Dengue Management among Medical and Paramedical Personnel Following Attendance to Educational Lectures

This study was carried out to assess the effectiveness of dengue talks to raise and improve knowledge of health care providers. This was a descriptive cross sectional study consisting of a pre and post test evaluation. Comparison of data was done with the McNemar test and independent T test. There were significant improvements in all knowledge sections among the overall health provider group. The pre test scores mean was higher among the doctors compared to paramedics.

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Effects of Vitamin E on Bone Oxidative Parameters during Fracture Healing of Postmenopausal Osteoporosis Rat Model

Osteoporosis increases the risk of bone fracture and may interfere fracture healing. Studies have proven that vitamin E promoted fracture healing of osteoporotic bone. The objective of this study is to determine whether the antioxidative actions of tocopherol and tocotrienol promotes the late-phase fracture healing of ovariectomised rats. Thirty-two female Sprague-Dawley (200g - 250g) rats were divided among four groups: Sham (SO), Ovariectomised-control (OVXC), Ovariectomised + 60mg/kg alpha-tocopherol (ATF), and ovariectomised + 60mg/kg tocotrienol enrich fraction (TEF).

Cardiovascular Demand of Roof Drilling Job in Coal Mines of Eastern India

Background: Reporting of cardiovascular stress on miners working as underground roof drillers in India is scanty. In this study the cardiac strain of 21 healthy roof drillers was evaluated during their actual work. Methods: Working heart rates (HRwork), relative cardiac cost (RCC), net cardiac cost (NCC), recovery heart rates (HRrec.) in two different work spells in a shift were measured for all the participants and compared between two age groups (< 40 years old and ³ 40 years old).

Clinical Features and Complications of Scorpion Sting: A Descriptive Study

Background: Scorpion sting is a common problem in rural parts of India. It is uncommon for patients with scorpion sting to present with life threatening complications.  This study aimed to describe the clinical manifestations and complications of scorpion sting. Methods: A descriptive study of clinical features and complications of patients diagnosed with scorpion sting and admitted in two hospitals attached to Jagadguru Jayadeva Murugarajendra (J.J.M) Medical College in Davangere, a state at the southern India.

Can we talk about it? Student’s willingness to share personal issues with a tutor

Background: The aim of this study was to investigate the degree of acceptability of the tutors by medical students and issues that the students are willing to discuss with their tutors.Methods: The study was conducted among first and third year medical students of a private medical university in Malaysia.  The study involved 76 students (100% response rate). The questionnaire had 16 questions which the student had to mark on a Likert 1 to 5 scale.

Tocotrineol Rich Fraction (TRF) Increases Viability of Senescent Fibroblast

The Hayflick limit is a theory that covers the definition of in vitro replicative senescence. It states that proliferating cells reach the limit of replicative potential after a series of sub-cultivations. Tocotrienol has been touted as it exhibits a higher significant radical scavenging activity as compared to α-tocopherols. In this study, we evaluated the effect of tocotrienol rich fraction (TRF) on the viability of young and senescent fibroblast and its possible modulation of oxidative stress.

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