Original articles

Recycled Deep-frying Oil Causes Blood Pressure Elevation and Vascular Hypertrophy in Sprague-Dawley Rats

Background: Recycling cooking oil for deep frying makes the oil more vulnerable to lipid peroxidation that generates oxidative com-pounds, linking to an increased risk of cardiovascular diseases. The study aimed to investigate the long-term effect of recycled deep-frying oil on blood pressure and aortic structure in rats.

Isolation of Mitochondria and Measurement of Oxygen Consumption Rate by High-resolution Respirometry in Rat Hippocampus

Background: Hippocampus plays an important role in memory and learning. Dysfunction of mitochondrial bioenergetics has been implicated in neurodegenerative disorders such Alzheimer disease. Oxygen consumption rate (OCR) is a useful indicator of mitochondrial function. Mitochondria isolated for OCR measurement need to have well intact function. This study aimed to describe the measurement of OCR by high resolution respirometry (HRR) in mitochondria isolated from rat hippocampus

Effect of Palm Tocotrienol Rich Fraction on Oxidative Status of Heart in a Rat Model of Isoprenaline-Induced Myocardial Injury

Background: Palm oil tocotrienol rich fraction (TRF) has shown potential as a cardioprotective, antioxidant, anti-inflammation, anti-ageing as well as anticancer agent through inhibiting free radical production and enhancing the antioxidant enzyme activity. Therefore, this study aimed to identify the effect of palm TRF on oxidative status in isoprenaline-induced myocardial injury in rats.

Beneficial Effects of Vitamin E in Diabetic Wound Healing

In diabetic condition, wound healing may be impaired or delayed due to high reactive oxygen species (ROS) and low antioxidant levels.
Vitamin E is an antioxidant which exerts both systemic and topical effects. The effects of vitamin E on wound healing remains controversial.
Numerous studies have been carried out to observe the ability of vitamin E in modulating signal transduction and gene expression.
However, the detailed molecular mechanisms are not yet clear. Vitamin E may promote healing by supressing ROS generation

Patterns of Dietary Supplement Use Among Gifted Student Population

Background: Dietary supplements consist of vitamins, minerals, herbs or amino acids. They complement diet and provide essential
nutrients for various health benefits. Publics should be educated on the role of dietary supplements in prevention and treatment of
chronic diseases such as osteoporosis, heart disease, cancer and neural tube defects. Therefore, information and knowledge on the pattern
of dietary supplements intake are important for physical and intellectual development. The objective of this study is to determine

Comparison of 24-hour Intraocular Pressure Control Between Timolol 0.5%, Brimonidine 0.2% and Latanoprost 0.005% in Patients with Primary Open Angle Glaucoma

Purpose: To compare the 24-hour intraocular pressure (IOP) control between timolol 0.5, brimonidine 0.2% %, and latanoprost 0.005% in patients with primary open angle glaucoma (POAG).

Prognostic Factors Of Patients with Upper Gastrointestinal Bleeding (UGIB) in Hospital Sultanah Nora Ismail, Johor

Patients with upper gastrointestinal bleeding (UGIB) has high risk of mortality despite the advancement in technology and treatment options. This study was conducted to identify the prognostic factors of patients with UGIB. This retrospective (record review) study involved patients diagnosed with UGIB between 1st January 2011 and 31st December 2013 in adult wards (surgical, medical and orthopedic) and intensive care unit. Individual and clinical characteristics were the variables under study and outcome was taken as time of diagnosis till death due to the disease.

Changes in Visual Field Defect : Post-Pituitary Tumor Resection Comparison Between Transphenoidal and Transcranial Approaches

To compare patients with pituitary adenoma who underwent transphenoidal (TS) and transcranial (TC) surgery, the visual outcome and postoperative complications. Retrospective analysis of case notes of 45 patients {(90 eyes) 14 TC, 31 TS} with pituitary adenoma who underwent pituitary tumour resection between 1998 and May 2002. The patients’ age ranged from 16 to 66 years with a mean ± SD of 41.7 ± 31.1 years. 56% are male. Fourteen patients were operated by TC. Preoperatively, visual acuity deficit occurred in 64% vs 96% (TS vs TC, p =0.011).

Effects of Prolonged Intravenous Phosphate Administration On Rabbit’s Serum Calcium

Phosphate administration mediates the genesis of the parathyroid gland hyperplasia thus modulating the parathyroid hormone synthesis. Phosphate retention will consequently lead to hyperparathyroidism which can be detected by markedly high serum calcium levels. The objective of this study is to evaluate the effects of prolonged intravenous phosphate administration on serum calcium and to establish the hyperparathyroidism animal model of rabbits. Ten healthy New Zealand White does (female rabbits) aged 4 months with body mass between 2.0 to 2.5 kg were used.

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